Award
National Institute of Allergy and Infectious Diseases 2R01AI151167-05A1
Manipulating alpha(v) integrins on B cells to promote lung-resident B cell responses
Recipient
Seattle Children's Hospital, Seattle, WA, United States
Award Amount
$767,781.00
Ceiling
$767,781.00
Awarded
March 27, 2026
Identifier
2R01AI151167-05A1
The award supports research on enhancing lung-resident B cell responses by manipulating alpha(v) integrins to improve immunity against respiratory viruses, aiming to develop better vaccines and therapeutic strategies.
Description
This project aims to investigate how B cell TLR signaling promotes germinal center responses, establish the protective capacity of lung-resident B cells, and evaluate αv antagonists in mice and human B cell cultures to enhance mucosal immune responses. The research addresses mechanisms promoting respiratory immunity and explores therapeutic strategies to enhance tissue-resident immune responses, potentially leading to new vaccine adjuvants.