Award
National Heart, Lung, and Blood Institute 1R01HL184037-01
Genetic Architecture of Natriuretic Peptides and Blood Pressure Response
Recipient
University of Alabama at Birmingham
Award Amount
$734,986.00
Ceiling
$734,986.00
Awarded
August 06, 2026
Identifier
1R01HL184037-01
The award funds a research project to study the genetic basis of natriuretic peptides and their impact on blood pressure regulation, including clinical trials to personalize hypertension treatment.
Description
This project aims to describe the genetic architecture of natriuretic peptides (NPs), generate and validate polygenic risk scores (PGS), and examine their association with cardiometabolic and cardiovascular outcomes. It includes a genotype-guided trial with hypertensive individuals to assess blood pressure response to dietary salt and volume loading, potentially leading to personalized therapies.