Award
National Institute of Neurological Disorders and Stroke 5R01NS132780-03
Investigation of ecDNA as a driver of intratumoral heterogeneity and treatment resistance in high-risk medulloblastoma
Recipient
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Award Amount
$636,772.00
Ceiling
$636,772.00
Awarded
August 15, 2025
Identifier
5R01NS132780-03
Research project funded by NIH/NINDS investigating the role of ecDNA in medulloblastoma to understand tumor heterogeneity and treatment resistance, aiming to develop novel therapeutic strategies.
Description
The project focuses on extrachromosomal DNA (ecDNA) in medulloblastoma to understand tumor heterogeneity and treatment resistance using novel computational and imaging methods. It includes multiple aims: molecular evolution of ecDNA, combinatorial therapies, and functional inhibition. The research addresses limitations of current standard treatments for medulloblastoma.