NIH Reporter #1R21HL188689-01

Derivation and validation of a clinical prediction rule to identify febrile children and adolescents with sickle cell disease at low risk for bacteremia

This NIH/NHLBI funded project at Yale University seeks to create and validate a clinical prediction rule to identify febrile children with sickle cell disease at low risk for bacteremia, aiming to reduce unnecessary antibiotic use and hospitalizations.

Description

The project aims to develop a clinical prediction rule to identify children with sickle cell disease and fever at low risk for blood infection who can be safely discharged without antibiotics. It involves deriving and validating a clinical prediction rule using demographic, clinical, and laboratory data from the PECARN Registry and external validation in a multicenter prospective study.

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