Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R21HD118444-01
Defining the association between trisomy 21 and placentation defects
Recipient
University of Colorado, Boulder, CO, United States
Award Amount
$430,375.00
Ceiling
$430,375.00
Awarded
July 17, 2025
Identifier
1R21HD118444-01
The award supports research to understand placental defects in Down’s Syndrome by studying gene expression and the role of NRIP1 in trophoblast differentiation, which may help reduce adverse pregnancy outcomes.
Description
This project aims to elucidate mechanisms underlying placental defects in Down’s Syndrome, potentially informing strategies to mitigate adverse pregnancy outcomes. The research focuses on identifying transcriptional differences in trisomy 21 implantation-stage trophoblasts and the role of NRIP1 in trophoblast differentiation using induced pluripotent stem cell lines and CRISPR/Cas9 techniques.