Award
NIH Reporter #1R01HL187284-01
A Novel Beta-Adrenergic Signaling Mechanism Drives Interleukin 17A (IL-17A) and Hypertension by Chronic Stress
Recipient
Texas A&M University Health Science Center
Award Amount
$758,499.00
Ceiling
$758,499.00
Awarded
August 21, 2026
Identifier
1R01HL187284-01
Research project funded by NHLBI to study a novel beta-adrenergic signaling mechanism in T-lymphocytes that drives IL-17A production and hypertension caused by chronic stress, aiming to understand signaling pathways and therapeutic targets.
Description
This project investigates a novel pathway involving norepinephrine signaling through β-adrenergic receptors on T-lymphocytes that replaces IL-6 in IL-17A production during stress, leading to hypertension. The research aims to elucidate the signaling mechanisms involving cyclic AMP, PKA, ERK1/2, and STAT3, with potential clinical implications for managing stress-related cardiovascular conditions.