Award
National Institute of Allergy and Infectious Diseases 5R37AI077595-18
Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation
Recipient
Boston Children's Hospital, Boston, MA, United States
Award Amount
$637,200.00
Ceiling
$637,200.00
Awarded
April 01, 2026
Identifier
5R37AI077595-18
NIH research grant funded by NIAID to study chromatin loop extrusion's role in antibody class switch recombination and somatic hypermutation, aiming to advance understanding of antibody maturation and Peyer's Patch germinal center antibodies.
Description
This NIH research grant project focuses on immunology and chromatin biology, specifically elucidating mechanisms of antibody gene regulation and mutation, employing advanced technologies and mouse models, with a focus on Peyer's Patches and chromatin dynamics.