Award
NIH Reporter #1K99NS146612-01
Investigating the Role of Tanycyte Barriers at the Circumventricular Organs in Health and Neuroinflammation.
Recipient
University of California, San Diego
Award Amount
$121,554.00
Ceiling
$121,554.00
Awarded
February 02, 2026
Identifier
1K99NS146612-01
NIH research grant awarded to University of California, San Diego to study tanycyte barriers in brain regions related to neuroinflammation and neuroendocrine regulation, with a focus on molecular mechanisms and inflammation effects.
Description
Research grant focused on neurovascular barriers and neuroinflammation. The project investigates tanycyte barrier formation and disruption, aiming to define molecular and cellular mechanisms underlying tanycyte barrier formation and its functional role in the median eminence, focusing on Claudin-10's role in maintaining barrier integrity and regulating ion permeability. It also explores how inflammation disrupts tanycyte-mediated barrier function and impacts hypothalamic regulation.