Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD111148-02
Does the maternal environment during viral infection and inflammation direct fetal T cell development and function?
Recipient
University of Vermont & St. College, Burlington, VT, United States
Award Amount
$390,641.00
Ceiling
$390,641.00
Awarded
August 11, 2025
Identifier
5R01HD111148-02
Research project investigating the impact of maternal viral infection and inflammation on fetal T cell development and long-term immune function changes using advanced single-cell analysis and a mouse model.
Description
This project aims to examine how maternal infection and inflammation influence fetal thymic development of gamma delta T cells, and whether these changes persist into neonatal and adult stages. Using a mouse model and single-cell proteogenomics, the study will delineate the effects of maternal immune activation on thymic gamma delta T cell transcriptional and epigenetic landscapes, mechanisms involved, and the impact of placental-tropic viral infection.