Award
NIH Reporter #5R35GM136637-05
Unfolded protein response in the model species Arabidopsis thaliana
Recipient
National Institute of General Medical Sciences (NIGMS)
Award Amount
$391,250.00
Ceiling
$391,250.00
Awarded
May 16, 2024
Identifier
5R35GM136637-05
Research project awarded by NIGMS to study unfolded protein response in Arabidopsis thaliana, aiming to develop models to understand UPR's role in growth, stress resistance, and cell death, contributing to therapeutics development.
Description
The project focuses on mechanisms that multicellular eukaryotes have evolved to grow and protect themselves from death and diseases caused by insufficiency and defects in secretory protein synthesis. The research involves the model plant species Arabidopsis thaliana. The project aims to develop whole-body UPR models to understand the impact of UPR in growth, stress resistance, and cell death. The long-term goal is to contribute to understanding UPR at the cellular level and in vivo, aiding in therapeutics development.