Award
National Institute of Allergy and Infectious Diseases 5R01AI137168-09
Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis
Recipient
Sloan-Kettering Institute for Cancer Research
Award Amount
$523,794.00
Ceiling
$523,794.00
Awarded
June 09, 2026
Identifier
5R01AI137168-09
Research project funded by NIAID to investigate how DPP8/9 inhibitors induce pyroptosis through inflammasome activation, aiming to uncover molecular mechanisms and potential therapeutic targets for immune-related diseases.
Description
This project aims to study the molecular mechanisms linking cell homeostasis and innate immunity, focusing on inflammasome activation. It hypothesizes that reductive stress and Xaa-Pro peptide accumulation serve as danger signals that activate inflammasomes, with a focus on the degradation of CARD8 and related pathways.