Award
NIH Reporter #5R01AR083343-03
Extracellular Matrix Regulation of Inflammatory Signaling in Tendon
Recipient
University of Michigan at Ann Arbor
Award Amount
$326,040.00
Ceiling
$326,040.00
Awarded
January 06, 2026
Identifier
5R01AR083343-03
NIH grant awarded to University of Michigan to develop a tendon-specific microphysiological system to study the role of extracellular matrix stiffness in inflammatory signaling and tendinopathy, aiming to inform therapeutic development.
Description
This application aims to engineer a novel tendon-specific microphysiological system to understand how loss of extracellular matrix stiffness increases inflammatory signaling in tendinopathy. Knowledge gained from these studies will inform development of therapeutic targets to treat tendon disease.