Award
National Cancer Institute 1F31CA298182-01A1
Functional Interrogation of Germinal Center Independent Memory B Cells in Head and Neck Cancer
Recipient
University of Pittsburgh at Pittsburgh, Microbiology/Immun/Virology
Award Amount
$49,538.00
Ceiling
$49,538.00
Awarded
July 16, 2025
Identifier
1F31CA298182-01A1
The award supports research on a specific subset of memory B cells in head and neck cancer to explore their role in tumor immunity and potential as targets for new immunotherapies.
Description
This project aims to identify and therapeutically modulate germinal center independent memory B cells (MBCs) in the tumor microenvironment of head and neck squamous cell carcinoma (HNSCC) to enhance antitumor immunity. The research focuses on understanding the function of these MBCs, which are a distinct subset that may contribute to tumor cell clearance and improve responses to immunotherapies such as anti-PD1 treatment and FcRL5 blockade.