National Institute of Allergy and Infectious Diseases 5R01AI171104-04

Selective Inhibitors of T Cell Activation Target Exportin-1 at Cys528 to Suppress Pathological T Cell Activation

NIH grant awarded to Case Western Reserve University for research on selective inhibitors of T cell activation targeting Exportin-1, funded by NIAID with $508,611 for FY 2026.

Description

This is a NIH grant opportunity for research on selective inhibitors of T cell activation targeting Exportin-1. The project aims to understand and optimize XPO1 partial antagonists for autoimmune diseases. The project involves structural, functional, and medicinal chemistry studies, as well as preclinical models. The funding is provided by NIAID, with a total budget of approximately $508,611 for FY 2026. The project is led by Drew James Adams, Assistant Professor at Case Western Reserve University.

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