Award
National Institute of General Medical Sciences 1R35GM158248-01
Molecular basis for CRISPR-associated transposons and RNA-guided transcriptional regulation
Recipient
Purdue University
Award Amount
$501,917.00
Ceiling
$501,917.00
Awarded
August 25, 2025
Identifier
1R35GM158248-01
This award funds research to understand the molecular mechanisms of CRISPR-associated transposons and RNA-guided gene regulation, aiming to develop advanced genome editing tools.
Description
Our research focuses on understanding the molecular mechanisms of RNA-guided biological systems, particularly CRISPR-associated transposons (CASTs) and RNA-guided gene regulation functions. Using cryo-electron microscopy and biochemical assays, we aim to dissect the interactions and structural dynamics of these systems. The project seeks to explore targeted DNA insertion mechanisms, structural basis of target recognition, and the development of programmable gene regulation tools, contributing to next-generation genome editing technologies.