Award
NIH Reporter #5R01AI159182-05
Structure-guided and epitope-based design of potent and broadly neutralizing nanobodies for COVID-19 mucosal immunotherapy
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$641,344.00
Ceiling
$641,344.00
Awarded
August 06, 2026
Identifier
5R01AI159182-05
NIH-funded research project to develop broadly neutralizing nanobodies for COVID-19 mucosal immunotherapy using structure-guided and epitope-based design targeting SARS-CoV-2 spike protein.
Description
This project focuses on the structure-guided and epitope-based design of nanobodies that are potent and broadly neutralizing against SARS-CoV-2, aiming to develop mucosal immunotherapy for COVID-19. The research involves multidisciplinary approaches including mucosal immunology, structural biology, and virology to characterize nanobodies targeting the spike protein of SARS-CoV-2 and related Betacoronaviruses. The goal is to identify conserved epitopes for vaccine and therapeutic development, with potential for inhaled prophylactic or therapeutic use.