Award
National Institute on Drug Abuse R01DA062274-02
Molecular interplay of HIV Tat, cocaine, and cART in microglial pyroptosis: Role of NLRP3 inflammasome
Recipient
University of Nebraska Medical Center
Award Amount
$448,062.00
Ceiling
$448,062.00
Awarded
January 30, 2026
Identifier
R01DA062274-02
This NIH grant supports research on the molecular mechanisms of HIV Tat, cocaine, and antiretroviral therapy in microglial pyroptosis, focusing on the NLRP3 inflammasome to find new treatments for NeuroHIV.
Description
The project focuses on neuroinflammation in NeuroHIV, specifically investigating the role of HIV proteins, antiretroviral drugs, and cocaine in microglial pyroptosis via the NLRP3 inflammasome. The research aims to elucidate molecular mechanisms and validate findings in vivo and ex vivo, potentially leading to new therapeutic targets for NeuroHIV and other neuroinflammatory diseases.