Award
National Institute on Aging PAR-25-332
GABAergic Circuit Targets for Modulating Entorhinal Cortex and Hippocampal Dynamics in Alzheimer's Disease
Recipient
New York University School of Medicine
Award Amount
$642,063.00
Ceiling
$642,063.00
Awarded
January 14, 2026
Identifier
PAR-25-332
A research project funded by the National Institute on Aging to study specific brain circuits vulnerable in early Alzheimer's Disease, aiming to develop neuromodulatory strategies to improve memory function and prevent cognitive decline.
Description
This project investigates GABAergic microcircuits within the CA1 region of the hippocampus, focusing on neurons driven by VIP+ and CCK+ inhibitory neurons. The goal is to understand their role in early Alzheimer's Disease and develop targeted neuromodulatory therapies. The study involves cross-species comparison, electrophysiology, in vivo imaging, and proteomics in human tissue.