Award
National Institute of Neurological Disorders and Stroke 5K08NS114172-05
Examining the Role of a Novel Long Noncoding RNA, linc02454, in Resistance of Glioblastoma to Temozolomide
Recipient
University of Southern California
Award Amount
$189,645.00
Ceiling
$189,645.00
Awarded
July 28, 2025
Identifier
5K08NS114172-05
A research project funded by the National Institute of Neurological Disorders and Stroke to study the role of linc02454 in glioblastoma resistance to temozolomide chemotherapy, aiming to improve treatment efficacy by targeting this long noncoding RNA.
Description
This project investigates the role of the long noncoding RNA linc02454 in glioblastoma resistance to the chemotherapy drug temozolomide (TMZ). The study aims to understand how linc02454 modulates chemoresistance through interaction with the gene CXCR4 and to evaluate its potential as a therapeutic target. The research includes molecular and cellular analyses, methylation studies, and treatment response assessments both in vitro and in vivo.