Award
National Heart, Lung, and Blood Institute 1R01HL185875-01
Humanization of the bone marrow vascular niche to study hematopoietic stem cell and vascular interactions and function
Recipient
University of Florida, Gainesville, FL
Award Amount
$597,817.00
Ceiling
$597,817.00
Awarded
July 07, 2026
Identifier
1R01HL185875-01
This NIH-funded project by the University of Florida aims to improve hematopoietic stem cell transplantation outcomes by developing a humanized bone marrow vascular niche model. The research focuses on neutralizing THBS1 to enhance stem cell function and engraftment, potentially benefiting patients lacking suitable donors or requiring engineered stem cells.
Description
The project aims to develop novel resources to improve hematopoietic stem cell transplantation and vascular function by utilizing a novel humanized in vivo vascular niche platform. The research focuses on neutralizing Thrombospondin-1 (THBS1) to enhance blood stem cell function, improve engraftment, and identify novel therapeutic factors. The project involves preclinical research with potential clinical applications to expand access to hematopoietic stem cell transplantation for patients with life-threatening blood disorders.