Award
NIH Reporter #5R01NS143814-03
Mechanisms of Claudin-5 Regulation during Neuroinflammation
Recipient
University of South Florida, Tampa, FL
Award Amount
$400,599.00
Ceiling
$400,599.00
Awarded
July 15, 2026
Identifier
5R01NS143814-03
NIH grant awarded to University of South Florida to study mechanisms of BBB dysfunction during neuroinflammation, focusing on FoxO1, nmMLCK, and HDAC6 roles and potential therapeutic targets.
Description
This project aims to investigate the cellular and molecular mechanisms by which FoxO1, nmMLCK, and HDAC6 contribute to blood-brain barrier (BBB) dysfunction during neuroinflammation, with a focus on diseases such as multiple sclerosis (MS). The research will utilize transgenic mice, pharmacologic approaches, and in vitro models to elucidate the pathways involved in BBB disruption and identify potential therapeutic targets.