Award
National Human Genome Research Institute 1R01HG014500-01
3D Chromatin architectural dynamics at ultra-high resolution
Recipient
Children's Hospital of Philadelphia, Philadelphia, PA, United States
Award Amount
$863,248.00
Ceiling
$863,248.00
Awarded
January 30, 2026
Identifier
1R01HG014500-01
Award for research on 3D chromatin dynamics to study genome folding and gene regulation using advanced techniques, funded by NHGRI, NIH.
Description
The project involves investigating 3D genome folding at ultra-high resolution to understand the relationship between 3D genome folding and gene regulation. It includes studies on microcompartments, heterochromatin, and chromatin organization, utilizing ultra-high resolution Region Capture Micro-C (RCMC), machine learning-based imputation, and super-resolution chromosome tracing.