Award
National Cancer Institute 4R01CA286469-03
Understanding lung cancer genomics in patients of African ancestry
Recipient
Sloan-Kettering Institute for Cancer Research
Award Amount
$2,191,178.00
Ceiling
$2,191,178.00
Awarded
July 07, 2026
Identifier
4R01CA286469-03
A NIH-funded research project by the National Cancer Institute awarded to Sloan-Kettering Institute for Cancer Research to study lung cancer genomics in patients of African ancestry, aiming to improve personalized treatment options through genomic and biomarker research.
Description
This research project focuses on genomic differences in lung cancer among African ancestry populations, emphasizing biomarker discovery and immunotherapy prediction. It aims to identify and validate genomic differences between patients with African and European ancestry, investigate the interaction between African ancestry and smoking exposure on somatic alterations, develop deep learning models to predict immunotherapy outcomes specific to ancestry, and use whole-genome sequencing and RNA-sequencing to discover new markers for patients of African ancestry.