Award
National Institute of Allergy and Infectious Diseases 1K99AI192939-01A1
Transcriptional Regulation of Immune-acting Fibroblasts
Recipient
University of California, San Diego
Award Amount
$184,520.00
Ceiling
$184,520.00
Awarded
August 06, 2026
Identifier
1K99AI192939-01A1
NIH grant awarded to University of California, San Diego to study transcriptional regulation of immune-acting fibroblasts involved in skin inflammation and infections, focusing on IL-17 and TNF cytokine effects.
Description
This project aims to investigate the transcriptional regulation of dermal immune-acting fibroblasts (IAFs) that are critical for neutrophil recruitment to the skin, in the context of type 17 inflammation. The study will focus on the roles of NF-κB p50 and IκBζ in IAF responses to IL-17 and TNF, with the goal of developing new therapeutic strategies for skin infections and inflammatory diseases.