NIH Reporter #1F32GM165117-01

A Radical Pathway Toward C-F Bond Functionalization: Direct Fluorine-Atom Transfer

The award supports research on innovative single-electron C-F bond functionalization methods to improve pharmaceutical synthesis by enabling late-stage modification of fluorine-containing compounds.

Description

This project aims to develop single-electron pathways toward C–F bond functionalization using radical cross-coupling, enabling late-stage modification of fluorine-containing motifs in APIs. The project involves electrochemically generated fluorophilic radical reagents to promote fluorine-atom abstraction, generating C-centered radical intermediates for streamlined synthesis of medicinally relevant motifs.

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