NIH Reporter #5R01ES037332-02

Prenatal Exposure to Organophosphate Ester Flame Retardants and Plasticizers (OPEs), Gene-Environment Interaction, and Child Neurodevelopment

Research grant to study gene-environment interactions affecting child neurodevelopment related to prenatal exposure to organophosphate ester flame retardants, using genetic methods to identify high-risk groups.

Description

This project proposes a novel application of two genetic methods—a genome-wide by environment interaction study and polygenic scores—to study how maternal and fetal genetics may modify the association between prenatal exposure to organophosphate ester flame retardants and child neurodevelopment. The knowledge gained will lead to better identification of high-risk mothers and children and guide development of strategies to protect sensitive subgroups.

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