Award
National Institute of Neurological Disorders and Stroke 4R01NS076815-13
Endocannabinoids in neurodegenerative diseases
Recipient
University of Texas Health Science Center, San Antonio, TX
Award Amount
$704,092.00
Ceiling
$704,092.00
Awarded
June 03, 2026
Identifier
4R01NS076815-13
Research project funded by the National Institute of Neurological Disorders and Stroke to study the anti-inflammatory and neuroprotective effects of MAGL inhibition in animal models of Alzheimer's Disease, focusing on cell type-specific mechanisms in astrocytes.
Description
This project focuses on the neuroprotective effects of MAGL inhibition in Alzheimer's Disease (AD), with a focus on cell type-specific mechanisms, especially in astrocytes, and aims to advance therapeutic strategies for AD. The research will evaluate beta-amyloid and tau pathology, synaptic plasticity, and cognitive function, contributing to the development of efficacious therapies for AD.