Award
NIH Reporter #5R01GM143260-04
Integrated stress response and the circadian clock
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$329,700.00
Ceiling
$329,700.00
Awarded
June 27, 2025
Identifier
5R01GM143260-04
Research project funded by NIGMS to study the interaction between integrated stress response and circadian clock in neurons, focusing on mechanisms affecting neuronal health and disease using mouse models.
Description
This project aims to elucidate mechanisms between the integrated stress response (ISR) and circadian timekeeping in neurons. It explores how circadian rhythms regulate neuronal differentiation, plasticity, and tissue regeneration, and how disruption contributes to health problems. The research will investigate the role of ISR components such as IMPACT, PERK, and eIF2 in circadian regulation using molecular, cellular, and behavioral approaches with mouse models.