Award
National Heart, Lung, and Blood Institute 5R01HL155325-05
Contribution of pulmonary ionocytes and neuroendocrine cells to ion transport-mediated airway surface liquid maintenance
Recipient
National Jewish Health, Denver, CO, United States
Award Amount
$477,491.00
Ceiling
$477,491.00
Awarded
April 09, 2025
Identifier
5R01HL155325-05
Research project funded by NHLBI to study the role of pulmonary ionocytes and neuroendocrine cells in airway ion transport and surface liquid maintenance, aiming to identify new therapeutic targets for airway diseases.
Description
This project aims to define the roles of rare airway epithelial cell types, including pulmonary ionocytes and neuroendocrine cells, in ion transport and airway surface liquid regulation, utilizing novel murine models and innovative techniques. It focuses on understanding ion transport across the epithelium vital to airway health and function, with implications for diseases such as cystic fibrosis, COPD, and asthma.