Award
National Institute of General Medical Sciences 1F32GM165071-01
Uncovering the Role of Intrinsically Disordered Regions in Regulating FOXG1-Chromatin Binding Dynamics
Recipient
STATE UNIVERSITY OF NEW YORK AT BUFFALO
Award Amount
$76,780.00
Ceiling
$76,780.00
Awarded
June 01, 2026
Identifier
1F32GM165071-01
This award supports research on how intrinsically disordered regions affect FOXG1 transcription factor function and chromatin binding, with implications for neurodevelopmental disorders.
Description
The project investigates the role of intrinsically disordered regions (IDRs) on FOXG1 chromatin binding, nuclear organization, and function in gene regulation. FOXG1 is a transcriptional repressor involved in neurodevelopment and neurodevelopmental disorders. The study aims to understand how IDRs influence FOXG1 function through phase separation and nuclear condensate formation, using computational, biophysical, and cellular approaches.