Award
NIH Reporter #1R01NS144133-01A1
Interaction between high-risk atherosclerotic plaque, reduced brain perfusion, and cognitive decline
Recipient
University of Washington
Award Amount
$647,418.00
Ceiling
$647,418.00
Awarded
August 26, 2026
Identifier
1R01NS144133-01A1
A research project funded by the National Institute of Neurological Disorders and Stroke to study the mechanisms of vascular cognitive impairment and dementia using advanced MRI techniques, aiming to develop targeted treatments.
Description
This project aims to differentiate between vascular cognitive impairment and dementia (VCID) caused by reduced brain blood flow and thromboembolism using MRI-based measurements of atherosclerosis, blood flow, and brain lesions. It will assess high-risk carotid plaque features and intracranial macro-vasculature to develop patient-specific treatment strategies, including evaluating the potential of GLP-1 receptor agonists to slow cognitive decline.