National Institute of Allergy and Infectious Diseases 5K08AI197864-02

Deciphering interactions between human T cells and cardiomyocytes in immune checkpoint inhibitor-related myocarditis

The award supports research to determine the drivers of irMyocarditis and therapeutically modulate interactions between T cells and cardiomyocytes using patient samples and model systems, aiming to reduce immune-related adverse events without affecting cancer treatment efficacy.

Description

This project focuses on understanding the mechanisms of immune checkpoint inhibitor-related myocarditis (irMyocarditis) caused by immune checkpoint inhibitors, aiming to develop targeted therapies that mitigate adverse effects while preserving anti-tumor responses. The research involves patient samples, human models, spatial profiling, and co-culture systems, with a planned clinical trial to test candidate treatments.

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