Award
National Cancer Institute 1OT2CA320062-01
WP2 - Define and Synthesize
Recipient
Harvard University
Award Amount
$839,584.00
Ceiling
$839,584.00
Awarded
June 11, 2026
Identifier
1OT2CA320062-01
This award funds the CAUSE project to identify DNA adducts causing unexplained mutational signatures in cancer, using advanced molecular and AI technologies to create a mechanistic atlas linking DNA damage to mutations, aiding cancer research and prevention.
Description
The Connecting Adducts, Unexplained Signatures, and Cancer Etiologies (CAUSE) project aims to mechanistically understand unexplained mutational signatures by systematically identifying specific DNA adducts and linking them to the mutations they generate. The project will build a high-throughput discovery platform integrating chemistry, biology, genomics, and cutting-edge technologies, focusing on endogenous processes, environmental exposures, and chemotherapy-induced DNA adducts. The project involves advanced molecular biology, chemistry, genomics, and AI technologies to create a comprehensive atlas linking DNA adducts to mutational signatures, with significant implications for understanding cancer etiology and improving prevention and treatment strategies.