Award
National Institute of General Medical Sciences 1R35GM163777-01
Membrane Editing for Deciphering Mechanisms of Phospholipid Homeostasis
Recipient
Cornell University
Award Amount
$258,713.00
Ceiling
$258,713.00
Awarded
June 23, 2026
Identifier
1R35GM163777-01
The award supports research to understand phospholipid homeostasis in eukaryotic cells by developing tools to visualize and manipulate phosphatidic acid, a key phospholipid involved in signaling and metabolism, to study its role in cellular function and disease.
Description
This project aims to develop molecular technologies to understand how cells regulate phospholipid metabolism and transport, focusing on phosphatidic acid (PA). The research involves visualizing PA biosynthesis, interorganelle lipid transport, and controlling PA synthesis spatiotemporally to elucidate mechanisms of phospholipid homeostasis and their role in disease.