Award
National Institute on Drug Abuse 5R21DA062828-02
Biochemically counteracting maladaptive functions of G9a/GLP in addiction
Recipient
University of California, San Francisco
Award Amount
$213,663.00
Ceiling
$213,663.00
Awarded
March 27, 2026
Identifier
5R21DA062828-02
Research project funded by NIH to develop addiction therapies by targeting G9a/GLP functions using advanced biochemical techniques.
Description
This project aims to define molecular surfaces to disrupt G9a/GLP dimers or modulate their residence on chromatin, informing the design of addiction therapies that avoid toxicity associated with enzyme inhibitors. The project involves cryo-electron microscopy, crosslinking mass spectrometry, and biochemical characterization.