Award
National Institute on Aging 5R01AG082681-04
Role of p21 positive senescent cells in radiation-induced skeletal injury and repair
Recipient
Mayo Clinic Rochester
Award Amount
$403,500.00
Ceiling
$403,500.00
Awarded
April 03, 2026
Identifier
5R01AG082681-04
The project aims to assess if acute removal of p21+ senescent cells can prevent chronic skeletal damage and promote fracture healing in elderly cancer survivors receiving radiation treatment.
Description
This project investigates the role of p21+ senescent cells in radiation-induced skeletal injury and explores targeted clearance strategies to mitigate adverse effects and promote bone healing in aging populations.