Award
NIH Reporter #5R01NS131782-03
Defining the role of Tox3 in congenital cerebellar hypoplasia and ataxia
Recipient
Cedars-Sinai Medical Center
Award Amount
$462,744.00
Ceiling
$462,744.00
Awarded
August 31, 2026
Identifier
5R01NS131782-03
NIH awarded a research grant to Cedars-Sinai Medical Center to study the role of the TOX3 gene in cerebellar development and its link to ataxia using advanced single-cell sequencing and epigenetic analysis.
Description
The project aims to investigate the role of the TOX3 gene in cerebellar development, specifically its impact on the generation of cerebellar granule cells from the rhombic lip. Loss of TOX3 results in almost complete agenesis of these cells and ataxia. The research will utilize single-cell approaches, including CUT&RUN for histone marks and multimodal single-cell RNA- and ATAC-sequencing, to uncover the genetic networks and epigenetic mechanisms regulated by TOX3.