Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R56DK136728-01
Impact of dysbiotic and symbiotic catabolism of luminal amino acids on intestinal epithelial barrier function and inflammation
Recipient
University of Kentucky, Lexington, KY, United States
Award Amount
$375,080.00
Ceiling
$375,080.00
Awarded
September 20, 2023
Identifier
1R56DK136728-01
The award funds research on how bacterial metabolites affect intestinal barrier function and inflammation, aiming to develop new therapies for inflammatory bowel diseases by studying specific molecular pathways and bacterial products.
Description
This project explores bacterial metabolites' role in intestinal health, aiming to develop microbiome-based therapies for gastrointestinal diseases. It focuses on the role of dysbiotic and symbiotic catabolism of luminal amino acids in intestinal epithelial barrier function and inflammation, particularly in the context of inflammatory bowel diseases (IBD). The research investigates TRPV1 and TRPV3 pathways, polyamine-driven SUMOylation, and evaluates small molecules inhibiting cadaverine synthesis to reduce inflammation using knockout mice and novel antibacterial agents.