Award
NIH Reporter #5R01AI154274-05
Cellular Mechanism of Oxysterol-Binding Protein (OSBP) in Viral Proliferation: A Chemical Biology Approach
Recipient
University of Oklahoma Health Sciences Center, Oklahoma City, OK
Award Amount
$390,514.00
Ceiling
$390,514.00
Awarded
April 11, 2025
Identifier
5R01AI154274-05
Research project funded by NIAID to study the role of OSBP in viral replication and develop new antiviral strategies targeting RNA viruses including coronaviruses.
Description
The proposed research aims to define the cellular biology of the oxysterol-binding protein (OSBP) in viral proliferation. OSBP is a critical mediator in the replication of RNA pathogenic viruses, including coronaviruses. The research will explore how OSBP regulates innate antiviral responses, including mTORC1 activity, autophagy, protein translation, and RNA decay mechanisms, to develop novel antiviral strategies.