Award
National Eye Institute 5R21EY036537-02
Toward Targeting GPR31 and GPR39 Signaling in Diabetic Retinopathy
Recipient
Oakland University
Award Amount
$190,883.00
Ceiling
$190,883.00
Awarded
August 04, 2025
Identifier
5R21EY036537-02
NIH awarded a grant to Oakland University to study the role of GPR31 and GPR39 receptors in diabetic retinopathy, aiming to identify new therapeutic targets to reduce retinal vascular damage caused by diabetes.
Description
This project aims to investigate the role of G-coupled protein receptors GPR31 and GPR39, which are suggested receptors for 12/15-LO metabolites, in retinal vascular damage associated with diabetic retinopathy. The study explores whether these receptors contribute to vascular dysfunction and tests the effects of their gain or loss of function on retinal cells, hypothesizing that inhibiting these receptors could improve barrier function and reduce inflammation, oxidative stress, and VEGF levels, offering potential therapeutic targets for diabetic retinopathy.