Award
NIH Reporter #5R01DK098656-11
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and Aging
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$776,955.00
Ceiling
$776,955.00
Awarded
December 15, 2025
Identifier
5R01DK098656-11
Research project funded by NIDDK to study NAD+ metabolism's role in improving glucose homeostasis in obesity and aging, aiming to understand NAD+ biology and its therapeutic potential.
Description
This project tests the hypothesis that nicotinamide adenine dinucleotide (NAD+) metabolism can be targeted to improve physiology in aged and obese individuals. It involves characterizing the effects of changes in NAD+ availability on subcellular distribution and flux in glucose metabolism, mapping the distribution and metabolism of emerging NAD+ precursors, and studying the effects of manipulating the mitochondrial NAD+ pool in liver and skeletal muscle.