Award
National Institute of Allergy and Infectious Diseases 5U54AI170856-05
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral Dynamics
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$1,427,683.00
Ceiling
$1,427,683.00
Awarded
May 07, 2026
Identifier
5U54AI170856-05
Research project funded by NIH focusing on HIV structural biology and viral dynamics, conducted by University of Utah, Salt Lake City, with multiple research aims on HIV infection mechanisms and viral dynamics.
Description
To establish a productive infection, HIV-1 must enter the cell, copy its RNA genome into DNA, enter the nucleus, and integrate into the host cell DNA. Studies in this project will uncover currently unknown aspects of these processes in molecular detail, providing a foundation for the development of new anti-viral targets. The project will also characterize how the HIV-1 inhibitor lenacapavir binds the viral capsid and inhibits nuclear entry.