Award
National Institute of Neurological Disorders and Stroke 5R16NS134540-04
Sex-based differences of a high fat diet in Alzheimer's disease (AD): Can nilotinib reverse bioenergetic and neuropathological deficits?
Recipient
Nova Southeastern University, Fort Lauderdale-Davie, FL
Award Amount
$154,000.00
Ceiling
$154,000.00
Awarded
March 19, 2026
Identifier
5R16NS134540-04
Research project funded by NINDS to investigate sex-based differences in Alzheimer's disease related to high fat diet and evaluate nilotinib as a therapeutic agent.
Description
This project studies metabolic disorders as risk factors for Alzheimer's disease, focusing on sex differences in bioenergetic, cognitive, and neuropathological outcomes in 3xTg-AD mice on a high fat diet, and tests whether nilotinib can improve these outcomes.