Award
National Institute of General Medical Sciences 5R35GM148160-04
Cell and mechanobiology of Asymmetric Cell Division
Recipient
University of Washington, Seattle, WA
Award Amount
$376,659.00
Ceiling
$376,659.00
Awarded
December 19, 2025
Identifier
5R35GM148160-04
Research project funded by NIGMS to study asymmetric cell division mechanisms in Drosophila neuroblasts, focusing on cellular asymmetry and its impact on cell fate using advanced imaging and molecular techniques.
Description
This project investigates mechanisms involved in cellular and subcellular asymmetry, biased segregation of molecules and organelles, and their contribution to binary cell fate decisions, focusing on asymmetric cell division (ACD) in Drosophila neuroblasts. The research aims to understand how cortical flows are induced and modulated to achieve sibling cell size asymmetry, and how centrosome asymmetry influences cell fate, using advanced live cell imaging, superresolution microscopy, RNA sequencing, and optogenetics.