Award
National Institute of General Medical Sciences 5R35GM146883-04
Regulatory roles of the epitranscriptome and RNA structurome during vertebrate development
Recipient
University of Connecticut School of Medicine
Award Amount
$416,250.00
Ceiling
$416,250.00
Awarded
July 31, 2025
Identifier
5R35GM146883-04
This award funds research to study RNA modifications and structures in gene regulation during vertebrate development, focusing on the maternal-to-zygotic transition using zebrafish as a model organism.
Description
The project aims to understand how the epitranscriptome and RNA structures mediate gene regulatory networks during vertebrate development, using zebrafish as an in vivo model. It involves generating detailed maps of the epitranscriptome, deciphering RNA folds, identifying trans-factors interacting with RNA modifications and structures, and studying their effects on gene expression and development.