National Institute of Neurological Disorders and Stroke 5UH3NS123965-03

Novel, Non-Opioid, Non-Addictive Intrathecal Therapy for the Treatment of Chronic Pain

Award to CENTREXION THERAPEUTICS CORPORATION for developing a novel non-opioid intrathecal therapy for chronic pain, including preclinical and Phase 1 trial preparations.

Description

This project aims to develop a novel, small molecule, nociceptin receptor agonist for intrathecal delivery via an implanted pump to manage chronic severe intractable pain. The focus is on completing IND-enabling studies, including CMC and toxicology, followed by a Phase 1 trial. The project involves scaling up drug production, formulation development, stability studies, and toxicity testing in preclinical models to support clinical trials.

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