NIH Reporter #3R01GM127365-08S1

Structure and Function of Essential Nucleoprotein Complexes Along a Viral Genome Packaging Pathway

NIH funded research project studying the final step of genome packaging in dsDNA viruses to understand termination mechanisms, with implications for virology and cell biology.

Description

This project aims to study the genome packaging process of large double-stranded DNA viruses, including herpesviruses and bacteriophages, focusing on the final step of genome termination during packaging. Using biochemical, biophysical, single-molecule, and structural approaches, the research will investigate how the translocating motor recognizes the genome end, senses DNA length, and how finishing proteins promote end maturation and terminase ejection. The findings are expected to have broad implications in virology and cell biology due to the conserved nature of these processes across dsDNA viruses.

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