Award
National Institute of Neurological Disorders and Stroke 5R35NS111604-08
Environmental Biosensors in the Oligodendrocyte Lineage
Recipient
Advanced Science Research Center
Award Amount
$1,158,744.00
Ceiling
$1,158,744.00
Awarded
April 21, 2026
Identifier
5R35NS111604-08
Research project funded by NINDS to study how environmental signals affect oligodendrocyte progenitors and myelination, with the goal of developing regenerative therapies for neurological disorders.
Description
This project aims to understand the biology of oligodendrocyte lineage cells and develop myelin regenerative strategies. It addresses how chemical, metabolic, and physical environmental signals induce responses in progenitor cells, leading to myelination, proliferation, and differentiation. The study uses an interdisciplinary approach combining cell biology, biophysics, advanced imaging spectroscopy, nanotechnology, super-resolution microscopy, and transgenic models to uncover mechanisms of signal transduction and inform therapeutic development.