National Institute of Allergy and Infectious Diseases 5R01AI072429-18

Regulation of TLR trafficking for proper self versus non-self discrimination

NIH grant awarded to University of California Berkeley to study mechanisms regulating Toll-like receptor trafficking to prevent autoimmune diseases, with a focus on TLR7/8 and TLR9 responses to self nucleic acids.

Description

This NIH-funded research project focuses on discovering new mechanisms that, when disrupted, promote responses to self nucleic acids by Toll-like receptors (TLRs) and drive autoimmune diseases such as lupus, psoriasis, and rheumatoid arthritis. The project involves genome-wide CRISPR screens and molecular studies to define key steps limiting TLR7/8 and TLR9 responses to self nucleic acids.

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