Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR084208-03
Exploring modulation of Lamin A/C protein lifetime as a novel axis of regulation in health and disease
Recipient
University of California, San Francisco
Award Amount
$441,972.00
Ceiling
$441,972.00
Awarded
January 23, 2026
Identifier
5R01AR084208-03
NIH grant awarded to University of California, San Francisco to study Lamin A/C protein lifetime modulation and its role in health and disease, including laminopathies and aging-related diseases.
Description
The project investigates the role of Lamin A/C proteins in nuclear structure and disease, focusing on how protein lifetime varies across tissues and influences laminopathies such as Hutchinson-Gilford Progeria Syndrome. The research aims to understand tissue vulnerability, protein stability, and the impact of Lamin A/C on chromatin organization.